Hydrogen sulfide prevents hydrogen peroxide-induced activation of epithelial sodium channel through a PTEN/PI(3,4,5)P3 dependent pathway.
Sodium reabsorption through the epithelial sodium channel (ENaC) at the distal segment of the Cleaning kidney plays an important role in salt-sensitive hypertension.We reported previously that hydrogen peroxide (H2O2) stimulates ENaC in A6 distal nephron cells via elevation of phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) in the apical mem